KEGG   REACTION: R00937
Entry
R00937                      Reaction                               
Name
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Definition
Tetrahydrofolate + 2 NAD+ <=> Folate + 2 NADH + 2 H+
Equation
C00101 + 2 C00003 <=> C00504 + 2 C00004 + 2 C00080
Comment
two-step reaction (see R00936+R02235)
NADP+ (see R00940)
Reaction class
RC00001  C00003_C00004
RC00110  C00101_C00504
Enzyme
1.5.1.3
Pathway
rn00670  One carbon pool by folate
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3
     R00937  Tetrahydrofolate + 2 NAD+ <=> Folate + 2 NADH + 2 H+
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (8402)   
   KEGG ORTHOLOGY (7)   
   KEGG GENES (8395)   
All databases (8419)   

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